Learn about displays how Y-box binding protein 1 promotes most cancers metastasis

Study reveals how Y-box binding protein 1 promotes cancer metastasis
YB1 triggers cellular invasion and cancermetastasis by means of regulating the miRNA200/205b-ZEB axis. Credit score: LIU Xiumei and CHEN Di

Metastasis of most cancers is the principle explanation for most cancers related dying in addition to the principle problem of most cancers remedy.

Lately, a gaggle led by means of Prof. Piao Hailong from the Dalian Institute of Chemical Physics (DICP) of the Chinese language Academy of Sciences (CAS) published that the nucleotide binding protein Y-box binding protein 1 (YB1) can advertise the metastasis of liver by means of regulating the biosynthesis of microRNA (miRNA).

This find out about was once printed in Most cancers Communications on June 10.

The researchers discovered that YB1 may just considerably inhibit the biosynthesis and expression of miRNA-200b and miRNA-205 by means of interacting with miRNA microprocessor complicated DgCR8, Dicer and terminal UTP transferase TUTs. Then, it up-regulated the expression of zinc-finger E-box binding homeobox 1 (ZEB1), which is a key for most cancers metastasis.

The advance of lung most cancers metastasis was once simulated by means of a injected via tail vein, and the researchers discovered that YB1 may just advertise lung metastasis of hepatocellular carcinoma cells.

Moreover, transcriptomics knowledge of medical tissues confirmed that the expression of YB1 was once undoubtedly correlated with ZEB1 in liver most cancers tissues, and negatively correlated with the expression of miRNA200 and miRNA205b. The miRNA200/205b-ZEB1 signaling pathway was once considerably correlated with the analysis of sufferers.


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Additional information:
Xiumei Liu et al, YB1 regulates miR‐205/200b‐ ZEB1 axis by means of inhibiting microRNA maturation in hepatocellular carcinoma, Most cancers Communications (2021). DOI: 10.1002/cac2.12164

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Chinese Academy of Sciences


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