Consistent with ARRS’ American Magazine of Roentgenology (AJR), a discounted dose of gadobutrol is non-inferior to 100%-standard dose of gadoterate for contrast-enhanced mind MRI.
“A 25% decreased gadobutrol dose demonstrated non-inferior efficacy as opposed to common dose gadoterate for contrast-enhanced mind MRI,” corresponding creator Jan Endrikat of Germany’s College Clinical College of Saarland elaborated, “warranting explicit attention in patients present process more than one contrast-enhanced examinations.”
On this global, potential, multicenter, open-label, crossover trial (LEADER-75), 141 sufferers (78 males, 63 ladies; imply age, 58.5 years) with identified or suspected CNS pathology underwent contrast-enhanced mind MRI with standard-dose gadoterate (0.1 mmol/ kg). If an improving lesion was once recognized, a 2d MRI with reduced-dose gadobutrol (0.075 mmol/kg) was once carried out inside 15 days.
Comparability of reduced-dose gadobutrol and standard-dose gadoterate as opposed to unenhanced imaging demonstrated noninferiority the usage of 20% margin for 3 number one efficacy measures: subjective lesion enhancement, lesion border delineation, lesion inside morphology.
Moreover, in post-hoc research, imply readings for subjective lesion enhancement, lesion border delineation, and lesion inside morphology differed via lower than 1%—supporting equivalence the usage of a slender ±5% margin.
“More than a few secondary variables additionally supported non-inferiority of reduced-dose gadobutrol,” the authors of the AJR article added.
Benjamin P. Liu et al, Medical Efficacy of Decreased Dose Gadobutrol As opposed to Same old Dose Gadoterate for Distinction-Enhanced MRI of the CNS: An World Multicenter Potential Crossover Trial (LEADER-75), American Magazine of Roentgenology (2021). DOI: 10.2214/AJR.21.25924
American Roentgen Ray Society
Decreased-dose gadobutrol vs standard-dose gadoterate for contrast-enhanced mind MRI (2021, June 17)
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