Benzodiazepines up chance for nonfatal drug-related poisoning in OUD

Benzodiazepines up risk for nonfatal drug-related poisoning in OUD

(HealthDay)—An higher chance for nonfatal drug-related poisoning is related to benzodiazepine remedy in sufferers with opioid use dysfunction, consistent with a learn about printed on-line March 3 in The American Magazine of Psychiatry.

Kevin Y. Xu, M.D., from the Washington College Faculty of Drugs in St. Louis, and co-workers used information from the IBM MarketScan database (2006 to 2016) to spot prescription claims in individuals (elderly 12 to 64 years) with who have been prescribed buprenorphine and who skilled drug-related poisoning.

The researchers discovered that buprenorphine remedy days have been related to a discount within the chance for poisoning occasions (odds ratio [OR], 0.63) relative to nontreatment days. Benzodiazepine remedy days have been related to an building up within the chance for such occasions (OR, 1.88). There used to be an building up observed in poisonings related to low-dose (OR, 1.78) and high-dose benzodiazepine remedy (OR, 2.22). Prime-dose benzodiazepine remedy used to be related to higher poisonings together with buprenorphine cotreatment (OR, 1.64), however this used to be less than the chance related to benzodiazepine remedy within the absence of buprenorphine (ORs, 1.69 and a pair of.23 for low-dose and , respectively).

“Dose relief of benzodiazepines whilst keeping up buprenorphine remedy will have the good thing about reducing drug-related chance,” the authors write.

Opioid overdose reduced in patients taking buprenorphine

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Benzodiazepines up chance for nonfatal drug-related poisoning in OUD (2021, April 2)
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